Q1: What is a VHPS series hydrogen peroxide sterilizer?

The VHPS series is an ambient-temperature biological decontamination and sterilization equipment independently developed by Hongji Clean. The device vaporizes 30%–35% high-concentration hydrogen peroxide solution into high-purity hydrogen peroxide vapor via a dedicated vaporizer, which is evenly delivered to enclosed spaces through pipelines to achieve all-round, dead-space-free sterilization. It is a compliant sterilization device specially designed for the cleanroom industry.

Q2: What is the core working principle of a VHPS sterilizer?

The device utilizes the significantly superior sporicidal efficacy of gaseous hydrogen peroxide compared to its liquid form. At room temperature, vaporized hydrogen peroxide releases a large number of free hydroxyl radicals, which actively attack and disrupt core cellular components such as lipids, proteins, and DNA of microorganisms, thereby completely eliminating all types of microorganisms and refractory spores, achieving thorough sterilization. The entire process operates at room temperature with no residual byproducts.

Q3: In what scenarios is the VHPS sterilizer suitable?

Widely used for ambient-temperature sterilization in various sealed clean environments, its primary applications include sterile transfer chambers, filling machines, freeze dryers, sterile isolators, GMP cleanrooms, biosafety laboratories, sealed sampling chambers, and other industrial and biomedical cleanroom scenarios.

Q4: What is the difference between vapor sterilization and conventional liquid hydrogen peroxide disinfection?

Conventional 3% liquid hydrogen peroxide can only achieve surface disinfection and is ineffective in eliminating spores or penetrating crevices and blind spots. In contrast, VHPS employs a high-concentration vaporization process with strong steam penetration capability, enabling coverage of equipment gaps, pipelines, and dead zones within cavities, thereby thoroughly eliminating spores. This constitutes a compliant sterilization process that meets GMP validation requirements.

Q5: What requirements does the device have for consumables?

A dedicated 30%-35% medical-grade hydrogen peroxide solution must be used; it should not be diluted arbitrarily or replaced with low-concentration consumables. Failure to meet the required concentration will significantly reduce sterilization efficacy, resulting in substandard sterilization performance and validation failure.

Q6: What is the standard operating procedure for VHPS sterilization?

1. Preliminary Preparation: Clean organic debris and oil stains from the space; seal all gaps; adjust temperature and humidity to optimal levels; evacuate personnel and place warning signs; 2. Environmental Adjustment: The equipment automatically dehumidifies and controls temperature to prevent vapor liquefaction; 3. Vaping Sterilization: Quantitatively vaporize hydrogen peroxide and deliver it to the sealed space for sterilization at a constant concentration under controlled conditions; 4. Residue Removal: Automatic exhaust system decomposes residual gases; safe entry is permitted once concentrations meet standards; 5. Effect Verification: Confirm sterilization compliance using biological and chemical indicators, with process records retained.

Q7: Will VHPS sterilization damage the equipment or building materials?

The device undergoes sterilization at ambient temperature throughout its operation and is compatible with the vast majority of clean materials, including stainless steel, glass, PP, PVC, conventional silicone, and precision electronic components, all of which can function normally. However, copper, brass, and galvanized metals are prone to oxidation upon prolonged contact; material compatibility testing should be conducted in advance for such applications.

Q8: What safety precautions should be observed when using a VHPS sterilizer?

All personnel involved in the sterilization process must evacuate the site and display warning signs. When adding high-concentration hydrogen peroxide, wear protective goggles and chemical-resistant gloves. Mixing with alcohol or chlorine-based disinfectants is strictly prohibited. After sterilization completion, thorough residual removal must be performed; only after residual levels meet standards may further operations commence.

Q9: What factors may lead to substandard sterilization efficacy?

Common causes: inadequate spatial sealing leading to steam leakage; residual organic matter in the chamber depleting effective sterilizing components; temperature and humidity exceeding process specifications; substandard concentration of consumables; blockage of equipment pipelines or obstruction of steam diffusion; and material stacking creating sterilization blind spots.

Q10: What are the core advantages of the VHPS sterilizer?

Ambient temperature sterilization, suitable for equipment intolerant to high temperatures and humidity; strong penetration capability of gaseous steam ensures no sterilization dead zones; post-sterilization decomposition occurs solely into water and oxygen with no residues or pollution; fully automated intelligent operation with traceable process parameters fully compliant with GMP and ISO cleanroom validation standards; multi-functional design adaptable to various types of sealed clean environments, demonstrating high versatility.

Q11: How should the equipment be maintained regularly?

Regularly inspect the spatial sealing rings and the sealing integrity of the conveying pipelines; calibrate temperature, humidity, and concentration sensors; perform periodic cleaning of the vaporizer to prevent scaling; promptly replace expired or deteriorated hydrogen peroxide consumables to ensure stable equipment operation.

Q12: Does it support customization for non-standard scenarios?

The system supports on-demand customization, enabling tailored pipeline configurations, drug delivery flow rates, and sterilization protocols based on the volume and layout of various facilities such as large cleanrooms, multiple isolators, or large freeze-dryers, providing an integrated sterilization solution.